Independent register of U.S. FDA drug recalls · updated Oct 10, 2026
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Cross-contamination

Traces of another drug - most often penicillin - got into the product from shared equipment or facilities. Even trace penicillin can trigger a severe allergic reaction in someone who was never meant to receive it.

782 FDA drug recalls with this cause, newest first.

Cross-contamination means a product picked up traces of a different drug during manufacturing, repackaging or handling - usually because equipment or a facility was shared. Penicillin is the classic case: it is a potent allergen, so FDA requires it to be made in fully separate facilities, and a single lapse can put every product that passed through the same line on the recall list. Most of these recalls are precautionary sweeps of everything a firm handled during the affected period, which is why one event can add hundreds of entries at once.

Class II · Moderate risk

Tri-Est 80:10:10 Progesterone

Penicillin Cross Contamination: Multiple finished products potentially contaminated with penicillin.

Terminated Cross-contamination South Coast Specialty Compounding, Inc. D-1407-2015
Class II · Moderate risk

Meloxicam capsules

Penicillin Cross Contamination: Multiple finished products potentially contaminated with penicillin.

Terminated Cross-contamination South Coast Specialty Compounding, Inc. D-1339-2015
Class II · Moderate risk

Leucovorin Calcium capsules

Penicillin Cross Contamination: Multiple finished products potentially contaminated with penicillin.

Terminated Cross-contamination South Coast Specialty Compounding, Inc. D-1338-2015
Class II · Moderate risk

Bi-Est 80:20 Progesterone

Penicillin Cross Contamination: Multiple finished products potentially contaminated with penicillin.

Terminated Cross-contamination South Coast Specialty Compounding, Inc. D-1337-2015
Class II · Moderate risk

Domperidone BP

Penicillin Cross Contamination: Potential for products to be cross-contaminated with penicillin.

Terminated Cross-contamination Freedom Pharmaceuticals Inc D-0567-2016
Class II · Moderate risk

Triest 80/10/10

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0228-2016
Class II · Moderate risk

Triest 80/10/10

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0227-2016
Class II · Moderate risk

Triest 70/20/10

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0226-2016
Class II · Moderate risk

Estriol 5 Estradiol

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0225-2016
Class II · Moderate risk

ESTRIOL (weight/volume)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0224-2016
Class II · Moderate risk

ESTRIOL (weight/volume)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0223-2016
Class II · Moderate risk

ESTRIOL (weight/volume)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0222-2016
Class II · Moderate risk

Estriol

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0221-2016
Class II · Moderate risk

ESTRIOL (Testosterone USP)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0220-2016
Class II · Moderate risk

ESTRIOL (Estradiol (E2)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0219-2016
Class II · Moderate risk

ESTRIOL (Estradiol (E2)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0218-2016
Class II · Moderate risk

ESTRIOL (Estradiol (E2)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0217-2016
Class II · Moderate risk

ESTRIOL (weight/volume)

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0216-2016
Class II · Moderate risk

Estriol

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0214-2016
Class II · Moderate risk

E2 (Estradiol

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0213-2016
Class II · Moderate risk

Biest Td 91/9

Recalled products were made using an active ingredient that was recalled by a supplier due to penicillin cross contamination.

Terminated Cross-contamination the Compounder D-0212-2016